#1
Publicado: Mié Ago 12, 2015 3:04 pm
Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome
By Marta Pozuelo et al. • www.ProHealth.com • August 11, 2015
By Marta Pozuelo et al.
Abstract
The pathophysiology of irritable bowel syndrome (IBS) remains unclear. Here we investigated the microbiome of a large cohort of patients to identify specific signatures for IBS subtypes.
We examined the microbiome of 113 patients with IBS and 66 healthy controls. A subset of these participants provided two samples one month apart. We analyzed a total of 273 fecal samples, generating more than 20 million 16S rRNA sequences.
In patients with IBS, a significantly lower microbial diversity was associated with a lower relative abundance of butyrate-producing bacteria (P?=?0.002; q?
Altogether, our findings showed that IBS-M and IBS-D patients are characterized by a reduction of butyrate producing bacteria, known to improve intestinal barrier function, and a reduction of methane producing microorganisms a major mechanism of hydrogen disposal in the human colon, which could explain excess of abdominal gas in IBS.
Articulo completo aqui: http://www.nature.com/srep/2015/150804/ ... 12693.html
By Marta Pozuelo et al. • www.ProHealth.com • August 11, 2015
By Marta Pozuelo et al.
Abstract
The pathophysiology of irritable bowel syndrome (IBS) remains unclear. Here we investigated the microbiome of a large cohort of patients to identify specific signatures for IBS subtypes.
We examined the microbiome of 113 patients with IBS and 66 healthy controls. A subset of these participants provided two samples one month apart. We analyzed a total of 273 fecal samples, generating more than 20 million 16S rRNA sequences.
In patients with IBS, a significantly lower microbial diversity was associated with a lower relative abundance of butyrate-producing bacteria (P?=?0.002; q?
Altogether, our findings showed that IBS-M and IBS-D patients are characterized by a reduction of butyrate producing bacteria, known to improve intestinal barrier function, and a reduction of methane producing microorganisms a major mechanism of hydrogen disposal in the human colon, which could explain excess of abdominal gas in IBS.
Articulo completo aqui: http://www.nature.com/srep/2015/150804/ ... 12693.html